Quay Street is a street in Manchester city centre in Greater Manchester, England. The street, designated the A34, continues Peter Street westwards towards the River Irwell and Salford. It is the northern boundary of Spinningfields, the city's business district and Castlefield, the historical area of the city, lies to the south. Quay Street was created in the 18th century for access to a quay on the river and is lined by several listed buildings.